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Article

Analysis of the intraclonal diversity of HLA-A0201-restricted T lymphocyte epitopes in follicular lymphoma idiotype.

British journal of haematology - 1 Feb 2006

Molinier-Frenkel Valérie, Popa Natalia, Poulot Virginie, Chaise Coralie, Marquet Jeanine, Haioun Corinne, Gaulard Philippe, Farcet Jean-Pierre, Delfau-Larue Marie-Hélène

Abstract excerpt

Lymphoma-derived immunoglobulin idiotype (Id) is a tumour-specific antigen used for antitumour vaccination in follicular lymphoma (FL). However, FL Ids are subject to hypermutation and subclones may escape antitumour cytotoxic T-cell response. To investigate the intraclonal epitope diversity, we sequenced the FL heavy chain gene (consensus Id gene) and subclones of 24 patients. The derived polypeptide sequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Genes, Immunoglobulin Heavy Chain

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Source

Identifiers

PMID: 16412018
DOI: 10.1111/j.1365-2141.2005.05861.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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