Article
Association of common LH variant with hyperfunctional promoter in a Japanese infertile woman.
Endocrine journal - 1 Dec 2005
Liu Shunyu, Ogata Tsutomu, Maruyama Tetsuo, Yoshimura Yasunori, Ishizuka Bunpei
Abstract excerpt
A common LH variant (V-LH) with Trp8Arg and Ile15Thr is often associated with ovarian dysfunction primarily in the Japanese population, and the LHB gene encoding V-LH is linked with a hyperfunctional promoter that could partly compensate for the somewhat weak biological effect of the V-LH in the Finnish and other several populations. We analyzed the promoter region in a Japanese infertile woman homozygous for the...
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