Article
An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2006
Kunicki T J, Baronciani L, Canciani M T, Gianniello F, Head S R, Mondala T S, Salomon D R, Federici A B
Abstract excerpt
We analyzed the association of bleeding severity with candidate gene haplotypes within pedigrees of 11 index cases of von Willebrand disease (VWD) type 2 (two type 2A, three type 2B and six type 2M), using the QTL Association model (MENDEL 5.5). In addition to the 11 index cases, these pedigrees included 47 affected and 49 unaffected relatives, as defined by VWF mutations and/or phenotype. A bleeding severity...
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