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Article

Propranolol disposition in the rat: variation in hepatic extraction with unbound drug fraction.

Journal of pharmaceutical sciences - 1 Mar 1992

Gariépy L, Fenyves D, Villeneuve J P

Abstract excerpt

The plasma protein binding of propranolol has been described as nonrestrictive for its hepatic extraction to explain the observation that propranolol is efficiently removed by the liver, in spite of extensive protein binding. The present study was designed to examine the relationship between propranolol protein binding, metabolism by isolated hepatocytes, and extraction by the isolated perfused rat liver. In...

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PMID: 1640364
DOI: 10.1002/jps.2600810314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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