Propranolol disposition in the rat: variation in hepatic extraction with unbound drug fraction.

doi:10.1002/jps.2600810314

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Article

Propranolol disposition in the rat: variation in hepatic extraction with unbound drug fraction.

Journal of pharmaceutical sciences - 1 Mar 1992

Gariépy L, Fenyves D, Villeneuve J P

Abstract excerpt

The plasma protein binding of propranolol has been described as nonrestrictive for its hepatic extraction to explain the observation that propranolol is efficiently removed by the liver, in spite of extensive protein binding. The present study was designed to examine the relationship between prop...

Topics

Animals
Blood Proteins
Erythrocytes
Genetic Variation
Liver
Male
Perfusion
Propranolol
Protein Binding
Rats
Rats, Inbred Strains

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