Article
Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.
EMBO reports - 1 Mar 2006
Accardi Rosita, Dong Wen, Smet Anouk, Cui Rutao, Hautefeuille Agnes, Gabet Anne-Sophie, Sylla Bakary S, Gissmann Lutz, Hainaut Pierre, Tommasino Massimo
Abstract excerpt
The E6 and E7 of the cutaneous human papillomavirus (HPV) type 38 immortalize primary human keratinocytes, an event normally associated with the inactivation of pathways controlled by the tumour suppressor p53. Here, we show for the first time that HPV38 alters p53 functions. Expression of HPV38 E6 and E7 in human keratinocytes or in the skin of transgenic mice induces stabilization of wild-type p53. This...
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