Article
Large-scale characterization of public database SNPs causing non-synonymous changes in three ethnic groups.
Human genetics - 1 Mar 2006
Ireland James, Carlton Victoria E H, Falkowski Matthew, Moorhead Martin, Tran Karen, Useche Francisco, Hardenbol Paul, Erbilgin Ayca, Fitzgerald Ron, Willis Thomas D, Faham Malek
Abstract excerpt
Single nucleotide polymorphisms (SNPs) that lead to non-synonymous changes in proteins may have functional effects and be subject to selection. Hence they are of particular interest in the study of genetic diseases. We have genotyped approximately 28,000 such SNPs in three ethnic populations (the HapMap plates) and ten primate species and analyzed these data for evidence of selection. We find SNPs predicted by...
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