Article
Development of an oligochip for genotyping human leukocyte antigen-B51 and its clinical application.
Genetic testing - 1 Jan 2005
Wang Yun-shan, Ma Xiao-li, Sun Shan-hui, Sun Yue, Yu Bing
Abstract excerpt
Human leukocyte antigen (HLA) has been associated with Behcet's disease (BD), among which HLA-B51 is the most strongly associated genetic marker. The sandwich hybridization technique was applied in the design of the specific oligonucleotide probes to ensure the specific and accurate results. The probe-spotted chip was hybridized with the polymerase chain reaction (PCR) amplicons including nine suballeles...
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