Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants.

Prenatal diagnosis - 1 Jan 2006

Grandone Elvira, Corrao Anna Maria, Colaizzo Donatella, Vecchione Gennaro, Di Girgenti Caterina, Paladini Dario, Sardella Luigi, Pellegrino Michele, Zelante Leopoldo, Martinelli Pasquale, Margaglione Maurizio

Abstract excerpt

OBJECTIVE: To evaluate the role of different polymorphic gene variants involved in homocysteine metabolism and plasma levels of homocysteine, folate and vitamin B12 in families from southern Italy with neural tube defects (NTDs). METHODS: Eighteen fathers, 15 NTD children and 60 women who had conceived NTD foetuses were investigated. A group of 100 adults and 43 apparently healthy children was used as control. At...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Homocysteine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neural Tube Defects

Share to Nutritional Status

Share to White People

Source

Identifiers

PMID: 16374895
DOI: 10.1002/pd.1359

Genes

MTHFR
CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants.PMID 16374895Read ↗

Metabolic effects of C677T and A1298C mutations at the MTHFR gene in Brazilian children with neural tube defects.Semantic proximity Read ↗

Genetic variation in genes of folate metabolism and neural-tube defect risk.Semantic proximity Read ↗

Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population.Semantic proximity Read ↗

Genetics of homocysteine metabolism and associated disordersSemantic proximity Read ↗

Genetics of homocysteine metabolism and associated disordersSemantic proximity Read ↗

Folate levels and N(5),N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study.Semantic proximity Read ↗

Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group.Semantic proximity Read ↗

Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population.Semantic proximity Read ↗

The impact of genetic and environmental factors on homocysteine levels in preterm neonates.Semantic proximity Read ↗

Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.Semantic proximity Read ↗

Evaluation of maternal serum folate, vitamin B12, and homocysteine levels andfactor V Leiden, factor II g.20210G>A, and MTHFR variations in prenatallydiagnosed neural tube defects.Semantic proximity Read ↗

Altered folate and vitamin B12 metabolism in families with spina bifida offspringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.