Article
Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.
Cell communication & adhesion - 1 Jan 2000
Han Zhiqiang, Xu Gang, Zhou Jianfeng, Xing Hui, Wang Shixuan, Wu Mingfu, Zhang Yongtao, Lu Yunping, Ma Ding
Abstract excerpt
p160ROCK, a kinase effector of Rho GTPase mediating RhoA-induced assembly of focal adhesions and stress fibers, plays an important role in the invasive process of various tumor cells. The purpose of this study was to investigate the role of p160ROCK in the invasive behaviors of human ovarian cancer cells and their metastasis. Transfection with a dominant-active form of p160ROCK mutant (p160ROCKDelta 3) enhanced...
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