Article
Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA method.
Malaria journal - 15 Dec 2005
Enevold Anders, Vestergaard Lasse S, Lusingu John, Drakeley Chris J, Lemnge Martha M, Theander Thor G, Bygbjerg Ib C, Alifrangis Michael
Abstract excerpt
BACKGROUND: Mutations in the haemoglobin beta-globin (HbB) and glucose-6-phosphate dehydrogenase (G6PD) genes cause widespread human genetic disorders such as sickle cell diseases and G6PD deficiency. In sub-Saharan Africa, a few predominant polymorphic variants of each gene account for a majority of these deficiencies. Examining at a larger scale the clinical importance of these independent genetic disorders,...
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