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Article

Helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stresses.

The Journal of biological chemistry - 10 Feb 2006

McGee David J, Kumar Sateesh, Viator Ryan J, Bolland Jeffrey R, Ruiz Julio, Spadafora Domenico, Testerman Traci L, Kelly David J, Pannell Lewis K, Windle Henry J

Abstract excerpt

The gastric human pathogen Helicobacter pylori faces formidable challenges in the stomach including reactive oxygen and nitrogen intermediates. Here we demonstrate that arginase activity, which inhibits host nitric oxide production, is post-translationally stimulated by H. pylori thioredoxin (Trx) 1 but not the homologous Trx2. Trx1 has chaperone activity that renatures urea- or heat-denatured arginase back to...

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PMID: 16354674
DOI: 10.1074/jbc.M506139200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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