Article
The unstable Hb Hammersmith or alpha 2 beta 2(42)(CD1)Phe----Ser observed in an Indian child; identification by HPLC and by sequence analysis of amplified DNA.
Hemoglobin - 1 Jan 1992
Cunningham T A, Baker F, Kobrinsky N L, Cepreganova B, Baysal E, Wilson J B, Huisman T H
Abstract excerpt
We have identified the unstable hemoglobin variant present in a Chipewayan Indian patient with severe hemolytic anemia as Hb Hammersmith or alpha 2 beta 2(42)(CD1)Phe----Ser. Her parents were normal. Identification was greatly facilitated by the use of reversed phase high performance liquid chrom...
Topics
- Base Sequence
- Chromatography, High Pressure Liquid
- DNA
- Female
- Gene Amplification
- Globins
- Hemoglobins, Abnormal
- Humans
- Indians, North American
- Mutation