Article
Lack of germ-line mutations at the specific BRCA1-IRIS coding sequence in 114 Spanish high-risk breast/ovarian families.
Familial cancer - 1 Jan 2005
de la Hoya Miguel, Fernández Juan Manuel, Sánchez de Abajo Ana, Tosar Alicia, Díaz-Rubio Eduardo, Caldés Trinidad
Abstract excerpt
A new BRCA1 locus product called BRCA1-IRIS has been identified recently. High-risk breast/ovarian families have not been screened for germ-line mutations at the specific BRCA1-IRIS coding sequence, as it was considered merely as part of BRCA1 intron 11. Here we report the first comprehensive screening of germ-line mutations in a cohort of 116 index cases from high-risk breast/ovarian families in which no...
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