Article
Genetic analysis of candidate modifier polymorphisms in Hb E-beta 0-thalassemia patients.
Annals of the New York Academy of Sciences - 1 Jan 2005
Sripichai Orapan, Whitacre Johanna, Munkongdee Thongperm, Kumkhaek Chutima, Makarasara Wattanan, Winichagoon Pranee, Abel Ken, Braun Andreas, Fucharoen Suthat
Abstract excerpt
Hemoglobin E (Hb E)-beta-thalassemia patients display a range of clinical severities, from nearly asymptomatic to transfusion-dependent thalassemia major. Given this clinical heterogeneity, additional genetic factors modifying disease severity remain to be discovered. Association studies are bein...
Topics
- Adolescent
- Adult
- Alleles
- Blood Proteins
- Child
- Child, Preschool
- China
- Epistasis, Genetic
- Erythropoietin
- Female
- GATA1 Transcription Factor
- Globins
- Hemoglobin E
- Homeodomain Proteins
- Humans