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Article

Genetic analysis of candidate modifier polymorphisms in Hb E-beta 0-thalassemia patients.

Annals of the New York Academy of Sciences - 1 Jan 2005

Sripichai Orapan, Whitacre Johanna, Munkongdee Thongperm, Kumkhaek Chutima, Makarasara Wattanan, Winichagoon Pranee, Abel Ken, Braun Andreas, Fucharoen Suthat

Abstract excerpt

Hemoglobin E (Hb E)-beta-thalassemia patients display a range of clinical severities, from nearly asymptomatic to transfusion-dependent thalassemia major. Given this clinical heterogeneity, additional genetic factors modifying disease severity remain to be discovered. Association studies are being conducted to elucidate the role of genetic polymorphisms as disease severity modifiers in Hb E-beta-thalassemia...

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PMID: 16339693
DOI: 10.1196/annals.1345.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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