Article
Expression and functional analysis of fibulin-1 (Fbln1) during normal and abnormal placental development of the mouse.
Placenta - 1 Jan 2000
Singh U, Sun T, Larsson T, Elliott R W, Kostka G, Fundele R H
Abstract excerpt
The extracellular matrix protein fibulin-1 (FBLN1) is an important component of blood vessel walls, as shown by the lethality of mice with homozygous targeted deletion of the Fbln1 gene. Here, we show that a murine placental overgrowth phenotype is associated with elevated Fbln1 transcript levels, suggesting that the gene and its product have a functional role in placentation. Fbln1 exhibits a specific expression...
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