Article
[Mechanism of AcrAB-TolC system mediated multiple antimicrobial resistance in Salmonella typhimurium].
Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2005
Guo Yun-Chang, Du Chun-Ming, Liu Xiu-Mei
Abstract excerpt
OBJECTIVE: To confirm AcrAB-TolC system mediated the multiple antimicrobial resistance in Salmonella typhimurium. METHODS: One-step knock-out of chromosomal method was used, to disrupt chromosomal genes, in Salmonella typhimurium wild strain X2. The acrAB gene and tolC gene were knocked out and two mutants of the delta acrABX2 and delta tolCX2 were produced. RESULTS: Results of E-test to two mutation strains and...
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