Article
Pharmacogenetics of drug-induced arrhythmias: a feasibility study using spontaneous adverse drug reactions reporting data.
Pharmacoepidemiology and drug safety - 1 Feb 2006
De Bruin Marie L, van Puijenbroek Eugene P, Bracke Madelon, Hoes Arno W, Leufkens Hubert G M
Abstract excerpt
PURPOSE: The bottleneck in pharmacogenetic research on rare adverse drug reactions (ADR) is retrieval of patients. Spontaneous reports of ADRs may form a useful source of patients. We investigated the feasibility of a pharmacogenetic study, in which cases were selected from the database of a spontaneous reporting system for ADRs, using drug-induced arrhythmias as an example. METHODS: Reports of drug-induced...
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