Article
The molecular basis of glucose-6-phosphate dehydrogenase deficiency.
Trends in genetics : TIG - 1 Apr 1992
Vulliamy T, Mason P, Luzzatto L
Abstract excerpt
With more than 300 different variants reported, the human enzyme glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) is one of the most polymorphic proteins known. An estimated 400 million people throughout the world are deficient in G6PD; numerous lines of evidence indicate that this is because female heterozygotes have a selective advantage in malaria infections. The cloning of the G6PD gene has made it...
Topics
- Amino Acid Sequence
- Biological Evolution
- Glucosephosphate Dehydrogenase Deficiency
- Humans
- Malaria, Falciparum
- Molecular Sequence Data
- Mutation
- Selection, Genetic