Article
Cytochrome gene polymorphisms, serum estrogens, and hot flushes in midlife women.
Obstetrics and gynecology - 1 Dec 2005
Visvanathan Kala, Gallicchio Lisa, Schilling Chrissy, Babus Janice K, Lewis Lynn M, Miller Susan R, Zacur Howard, Flaws Jodi A
Abstract excerpt
OBJECTIVE: The purpose of this study was to evaluate whether genetic polymorphisms in selected cytochrome P450 enzymes (CYPc17alpha, CYP1A1, and CYP1B1), estradiol (E2) levels, and estrone levels were associated with hot flushes. METHODS: Women with hot flushes were those aged 45-54 years who reported ever experiencing hot flushes (n = 354). Women without hot flushes were those aged 45-54 years who reported never...
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