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Typing African Relapsing Fever Spirochetes

1 Nov 2005

Abstract excerpt

Relapsing fever Borrelia spp. challenge microbiologic typing because they possess segmented genomes that maintain essential genes on large linear plasmids. Antigenic variation further complicates typing. Intergenic spacer (IGS, between 16S-23S genes) heterogeneity provides resolution among Lyme disease-associated and some relapsing fever spirochetes. We used an IGS fragment for typing East African relapsing fever...

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PMID: 16318724
DOI: 10.3201/eid1111.050483

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