Article
Pharmacogenomics and cardiovascular drugs: need for integrated biological system with phenotypes and proteomic markers.
European journal of pharmacology - 19 Dec 2005
Siest Gérard, Marteau Jean-Brice, Maumus Sandy, Berrahmoune Hind, Jeannesson Elise, Samara Anastasia, Batt Anne-Marie, Visvikis-Siest Sophie
Abstract excerpt
Personalized medicine is based on a better knowledge of biological variability, considering the important part due to genetics. When trying to identify involved genes and their products in differential cardiovascular drug responses, a five-step strategy is to be followed: 1) Pharmacokinetic-related genes and phenotypes (2) Pharmacodynamic targets, genes and products (3) Cardiovascular diseases and risks depending...
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