Cutaneous DNA delivery and gene expression in <i>ex vivo</i> human skin explants via wet-etch microfabricated microneedles

Abstract excerpt

Micro-needle arrays increase skin permeability by forming channels through the outer physical barrier, without stimulating pain receptors populating the underlying dermis. It was postulated that micro-needle arrays could facilitate transfer of DNA to human skin epidermis for cutaneous gene therapy applications. Platinum-coated "wet-etch" silicon micro-needles were shown to be of appropriate dimensions to create...

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