Article
The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth.
Journal of cell science - 1 Dec 2005
Kim Tae-Aug, Jiang Shuxian, Seng Seyha, Cha Kiweon, Avraham Hava Karsenty, Avraham Shalom
Abstract excerpt
The neuronal nuclear matrix protein, NRP/B, contains a BTB domain and kelch repeats and is expressed in primary neurons but not in primary glial cells. To examine the function of NRP/B in neurons, we analyzed the structure/function of the NRP/B-BTB domain and its role in neurite outgrowth. Based on three-dimensional modeling of NRP/B, we generated an NRP/B-BTB mutant containing three mutations in the conserved...
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