Article
[Prophylactic surgery for hereditary non-polyposis colorectal cancer].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen - 1 Dec 2005
Möslein G, Ohmann C, Wenzel M
Abstract excerpt
The most frequent hereditary colorectal cancer predisposition is Lynch syndrome, or hereditary non-polyposis colorectal cancer. The option of prophylactic surgery relies on the penetrance of the genetic defect and the heterogeneity of the condition. Since 20% of all mutation carriers never move on to develop cancer, the purely prophylactic setting is not indicated. However, when colorectal cancer is diagnosed,...
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