Article
[Prophylactic surgery of mammary and ovarian carcinoma].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen - 1 Dec 2005
Lux M P, Bani M R, Fasching P A, Beckmann M W
Abstract excerpt
New insights into the genetic basis of carcinogenesis have been obtained by modern molecular biological techniques. Several susceptibility genes are known. The hereditary breast and ovarian cancer syndrome (germline mutations in BRCA1 and BRCA2) and endometrial cancer in the context of the hereditary non-polyposis colorectal cancer syndrome (HNPCC), germline mutations in mismatch-repair genes, are the most...
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