Article
Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2000
Welty F K, Lichtenstein A H, Barrett P H, Jenner J L, Dolnikowski G G, Schaefer E J
Abstract excerpt
Subjects with the apolipoprotein (apo) E4 allele have been shown to have higher low density lipoprotein (LDL) cholesterol and apoB levels than do subjects with the other alleles. To elucidate the metabolic mechanisms responsible for this finding, we examined the kinetics of apoB-48 within triglyceride-rich lipoproteins (TRLs) and of apoB-100 within very low density lipoprotein (VLDL), intermediate density...
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