Article
Characterization, classification, and treatment of von Willebrand diseases: a critical appraisal of the literature and personal experiences.
Seminars in thrombosis and hemostasis - 1 Nov 2005
Michiels Jan Jacques, Gadisseur Alain, Budde Ulrich, Berneman Zwi, van der Planken Marc, Schroyens Wilfried, van de Velde Ann, van Vliet Huub
Abstract excerpt
Recessive type 3 von Willebrand disease (vWD) is a severe hemophilia-like bleeding disorder caused by homozygosity or double heterozygosity for two nonsense mutations (null alleles) and characterized by a strongly prolonged bleeding time (BT), absence of ristocetin-induced platelet aggregation (RIPA), absence of von Willebrand factor (vWF) protein, and prolonged activated partial thromboplastin time (APTT) due to...
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