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Article

Methylenetetrahydrofolate reductase gene mutations as risk factors for sudden hearing loss.

American journal of otolaryngology - 1 Jan 2000

Capaccio Pasquale, Ottaviani Francesco, Cuccarini Valeria, Ambrosetti Umberto, Fagnani Enrico, Bottero Alessandro, Cenzuales Salvatore, Cesana Bruno Mario, Pignataro Lorenzo

Abstract excerpt

Sudden hearing loss (SHL) can be caused by vascular disorders favoring impaired cochlear perfusion. Several inherited prothrombotic risk factors have been considered in the pathogenesis of vascular impairment, and the possible role of genetic alterations has recently been suggested. Methylenetetrahydrofolate reductase (MTHFR) gene mutations at nucleotides 677 and 1298 cause reduced MTHFR enzyme activity, which...

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Identifiers

PMID: 16275406
DOI: 10.1016/j.amjoto.2005.05.001

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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