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Article

Assessment of Low Linear Energy Transfer Radiation–Induced Bystander Mutagenesis in a Three-Dimensional Culture Model

1 Nov 2005

Abstract excerpt

A three-dimensional cell culture model composed of human-hamster hybrid (A(L)) and Chinese hamster ovary (CHO) cells in multicellular clusters was used to investigate low linear energy transfer (LET) radiation-induced bystander genotoxicity. CHO cells were mixed with A(L) cells in a 1:5 ratio and briefly centrifuged to produce a spheroid of 4 x 10(6) cells. CHO cells were labeled with tritiated thymidine...

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PMID: 16267011
DOI: 10.1158/0008-5472.can-04-2875

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