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Article

Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein.

Haematologica - 1 Nov 2005

Chiocchetti Annalisa, Gibello Luisa, Carando Adriana, Aspesi Anna, Secco Paola, Garelli Emanuela, Loreni Fabrizio, Angelini Mara, Biava Alessandra, Dahl Niklas, Dianzani Umberto, Ramenghi Ugo, Santoro Claudio, Dianzani Irma

Abstract excerpt

BACKGROUND AND OBJECTIVES: Diamond Blackfan anemia (DBA) is a congenital disease characterized by defective erythroid progenitor maturation. Patients' bone marrow progenitor cells do not respond to erythropoietic growth factors, such as erythropoietin. Mutations in the gene encoding for ribosomal protein (RP) S19 account for 25% of cases of DBA. The link between defective erythropoiesis and RPS19 is still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16266891

Genes

RPS19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein.PMID 16266891Read ↗

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Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.Semantic proximity Read ↗

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.Semantic proximity Read ↗

A novel nucleolar protein interacts with ribosomal protein S19.Semantic proximity Read ↗

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia.Semantic proximity Read ↗

Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.Semantic proximity Read ↗

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