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Article

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.

Blood - 15 Jun 2005

Flygare Johan, Kiefer Thomas, Miyake Koichi, Utsugisawa Taiju, Hamaguchi Isao, Da Costa Lydie, Richter Johan, Davey Edward J, Matsson Hans, Dahl Niklas, Wiznerowicz Maciej, Trono Didier, Karlsson Stefan

Abstract excerpt

Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have a mutation in the ribosomal protein S19 (RPS19) gene. To study effects of RPS19 deficiency in hematopoiesis we transduced CD34(+) umbilical cord blood (CB) and bone marrow (BM) cells with 3 lentiviral vectors expressing small interfering RNA (siRNA) against RPS19 and 1 scrambled control vector. All vectors also...

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Share to Anemia, Diamond-Blackfan
Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Differentiation, B-Lymphocyte

Share to Erythroid Precursor Cells

Share to Hematopoiesis

Share to Lentivirus

Share to Receptors, Transferrin

Share to Umbilical Cord

Source

Identifiers

PMID: 15626736
DOI: 10.1182/blood-2004-08-3115

Genes

RPS19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.PMID 15626736Read ↗

Ribosomal protein S19 deficiency leads to reduced proliferation and increased apoptosis but does not affect terminal erythroid differentiation in a cell line model of Diamond-Blackfan anemia.Semantic proximity Read ↗

Deficiency of ribosomal protein S19 during early embryogenesis leads to reduction of erythrocytes in a zebrafish model of Diamond-Blackfan anemia.Semantic proximity Read ↗

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Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.Semantic proximity Read ↗

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector.Semantic proximity Read ↗

Recent insights into the pathogenesis of Diamond-Blackfan anaemia.Semantic proximity Read ↗

Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency.Semantic proximity Read ↗

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Study of the effects of proteasome inhibitors on ribosomal protein S19 (RPS19) mutants, identified in patients with Diamond-Blackfan anemia.Semantic proximity Read ↗

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