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Article

PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome.

The Journal of clinical endocrinology and metabolism - 1 Sept 2005

Binder G, Neuer K, Ranke M B, Wittekindt N E

Abstract excerpt

CONTEXT: Noonan syndrome is frequently associated with an unclear disturbance of GH secretion. Half the individuals with Noonan syndrome carry a heterozygous mutation of the nonreceptor-type protein tyrosine phosphatase, Src homology region 2-domain phosphatase-2 (SHP-2), encoded by PTPN11, which has a role in GH receptor signaling. OBJECTIVE: The objective of this study was to compare GH secretion and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15985475
DOI: 10.1210/jc.2005-0995

Genes

PTPN11
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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