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Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva

25 Oct 2005

Abstract excerpt

The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and infects the oropharynx, we analyzed the transcriptome of a serotype M1 strain grown in saliva. The dynamic pattern of...

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PMID: 16249338
DOI: 10.1073/pnas.0505839102

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