Article
Multiple sclerosis in twins from continental Italy and Sardinia: a nationwide study.
Annals of neurology - 1 Jan 2006
Ristori Giovanni, Cannoni Stefania, Stazi Maria Antonietta, Vanacore Nicola, Cotichini Rodolfo, Alfò Marco, Pugliatti Maura, Sotgiu Stefano, Solaro Claudio, Bomprezzi Roberto, Di Giovanni Simone, Figà Talamanca Lorenzo, Nisticò Lorenza, Fagnani Corrado, Neale Michael C, Cascino Isabella, Giorgi Gabriele, Battaglia Mario A, Buttinelli Carla, Tosi Roberto, Salvetti Marco
Abstract excerpt
Knowledge about the balance between heritable and nonheritable risk in multiple sclerosis (MS) is based on twin studies in high-prevalence areas. In a study that avoided ascertainment limitations and directly compared continental Italy (medium-prevalence) and Sardinia (high-prevalence), we ascertained 216 pairs from 34,549 patients. This gives a twinning rate of 0.62% among MS patients, significantly less than...
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