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Article

Tangier disease: still more questions than answers.

Cellular and molecular life sciences : CMLS - 1 Oct 2005

Nofer J-R, Remaley A T

Abstract excerpt

High-density lipoproteins (HDLs) play a central role in transporting cholesterol from peripheral tissues to the liver for elimination from the body. Impairment of HDL-mediated cholesterol transport favors cholesterol deposition in the arterial wall and promotes development of arteriosclerosis. Tangier disease is a severe HDL deficiency syndrome characterized by the accumulation of cholesterol in tissue...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16235041
DOI: 10.1007/s00018-005-5125-0
PMCID: PMC11139120

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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ABCA1. The gatekeeper for eliminating excess tissue cholesterol.Semantic proximity Read ↗

ATP binding cassette transporter A1--key roles in cellular lipid transport and atherosclerosis.Semantic proximity Read ↗

A novel variant in the ABCA1 gene for Tangier Disease with diffuse histiocytosis of bone marrow.Semantic proximity Read ↗

A novel ABCA1 variant associated with impaired platelet production contributing to thrombocytopenia in a family with Tangier disease.Semantic proximity Read ↗

A novel mutation in the ABCA1 gene causing an atypical phenotype of Tangier disease.Semantic proximity Read ↗

ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?Semantic proximity Read ↗

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