Article
A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute.
Developmental biology - 1 Dec 2005
Gibert Jean-Michel, Marcellini Sylvain, David Jean R, Schlötterer Christian, Simpson Pat
Abstract excerpt
Traditional screens aiming at identifying genes regulating development have relied on mutagenesis. Here, we describe a new gene involved in bristle development, identified through the use of natural variation and selection. Drosophila melanogaster bears a pattern of 11 macrochaetes per heminotum. From a population initially sampled in Marrakech, a strain was selected for an increased number of thoracic...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Molecular Sequence Data
- Mutation
- Phenotype
- Promoter Regions, Genetic