Article
Growth and hepatic in vitro metabolism of ergotamine in mice divergently selected for response to endophyte toxicity.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2005
Duringer J M, Lewis R, Kuehn L, Fleischmann T, Craig A M
Abstract excerpt
This study investigated if genetic differences exhibited in endophyte-resistant and -susceptible mouse lines had persisted after 13 generations in which the integrity of lines was maintained yet selection ceased. Experimental groups were mouse lines fed an endophyte-free (E-) or -infected (E+) diet. The in vitro metabolism of the ergot alkaloid ergotamine in mouse liver microsomes was characterized by LC-MS/MS...
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