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Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

28 Sept 2005

Abstract excerpt

The Sleeping Beauty (SB) transposon system is a nonviral DNA delivery system in which a transposase directs integration of an SB transposon into TA-dinucleotide sites in the genome. To determine whether the SB transposon system can mediate stable gene expression in human T cells, primary peripheral blood lymphocytes (PBLs) were nucleofected with SB vectors carrying a DsRed reporter gene. Plasmids containing the...

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PMID: 16189271
DOI: 10.1182/blood-2005-05-2133

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