Article
Relationship between the level of acquired resistance to gentamicin and synergism with amoxicillin in Enterococcus faecalis.
Antimicrobial agents and chemotherapy - 1 Oct 2005
Aslangul Elisabeth, Ruimy Raymond, Chau Françoise, Garry Louis, Andremont Antoine, Fantin Bruno
Abstract excerpt
In enterococci, intrinsic low-level resistance to gentamicin does not abolish synergism with a cell wall-active antibiotic while high-level resistance due to acquired aminoglycoside-modifying enzymes does. To study the impact of intermediate levels of resistance to gentamicin (64 < MIC < 500 microg/ml), we selected in vitro three consecutive generations of mutants of Enterococcus faecalis JH2-2 with MICs of...
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