Article
Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages.
FEMS immunology and medical microbiology - 1 Nov 2012
Rosvoll Torill C S, Lindstad Belinda L, Lunde Tracy M, Hegstad Kristin, Aasnaes Bettina, Hammerum Anette M, Lester Camilla H, Simonsen Gunnar S, Sundsfjord Arnfinn, Pedersen Torunn
Abstract excerpt
Gentamicin is important in synergistic bactericidal therapy with cell wall agents for severe enterococcal infections. During 2003-2008, a 10-fold increase in the prevalence of high-level gentamicin resistance (HLGR), to above 50%, in blood culture isolates of Enterococcus faecium, was reported by the Norwegian Surveillance System for Antimicrobial Resistance. A representative national collection of invasive E....
Topics
- Acetyltransferases
- Anti-Bacterial Agents
- Cross Infection
- Drug Resistance, Bacterial
- Enterococcus faecium
- Genotype
- Gentamicins
- Gram-Positive Bacterial Infections
- Hospitals