Article
Conserved virulence of C to B capsule switched Neisseria meningitidis clinical isolates belonging to ET-37/ST-11 clonal complex.
Microbes and infection - 1 Jan 2006
Lancellotti Marcelo, Guiyoule Annie, Ruckly Corinne, Hong Eva, Alonso Jean-Michel, Taha Muhamed-Kheir
Abstract excerpt
Capsule switching in Neisseria meningitidis is thought to occur by horizontal DNA exchange between meningococcal strains. Antigenic variants may be generated by allelic replacement of the siaD gene; the variants may then be selected by specific immunity against the capsular antigen. There were several vaccination campaigns against serogroup C in France in 2002, following an increase in the prevalence of invasive...
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