Article
Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005.
The Journal of infectious diseases - 15 Apr 2010
Harrison Lee H, Shutt Kathleen A, Schmink Susanna E, Marsh Jane W, Harcourt Brian H, Wang Xin, Whitney Anne M, Stephens David S, Cohn Amanda A, Messonnier Nancy E, Mayer Leonard W
Abstract excerpt
BACKGROUND: A quadrivalent meningococcal conjugate vaccine (MCV4) was licensed in the United States in 2005; no serogroup B vaccine is available. Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups. METHODS: Meningococcal isolates from 10 Active Bacterial Core surveillance sites from 2000 through 2005 were...
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