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Article

Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.

Infection and immunity - 1 Oct 2005

Buchanan John T, Stannard Jason A, Lauth Xavier, Ostland Vaughn E, Powell Henry C, Westerman Mark E, Nizet Victor

Abstract excerpt

Streptococcus iniae represents a major health and economic problem in fish species worldwide. Random Tn917 mutagenesis and high-throughput screening in a hybrid striped bass (HSB) model of meningoencephalitis identified attenuated S. iniae mutants. The Tn917 insertion in one mutant disrupted an S. iniae homologue of a phosphoglucomutase (pgm) gene. Electron microscopy revealed a decrease in capsule thickness and...

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Identifiers

PMID: 16177373
DOI: 10.1128/IAI.73.10.6935-6944.2005
PMCID: PMC1230984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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