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Article

Evolution of the Capsular Operon of Streptococcus iniae in Response to Vaccination

23 Sept 2012

Abstract excerpt

Streptococcus iniae causes severe septicemia and meningitis in farmed fish and is also occasionally zoonotic. Vaccination against S. iniae is problematic, with frequent breakdown of protection in vaccinated fish. The major protective antigens in S. iniae are the polysaccharides of the capsule, which are essential for virulence. Capsular biosynthesis is driven and regulated by a 21-kb operon comprising up to 20...

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PMID: 23001668
DOI: 10.1128/aem.02216-12

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