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Article

Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 1999

Gemmati D, Previati M, Serino M L, Moratelli S, Guerra S, Capitani S, Forini E, Ballerini G, Scapoli G L

Abstract excerpt

Several studies have indicated that mild to moderate hyperhomocystinemia is a common cause of arterial occlusive disease. Whether hyperhomocystinemia per se is an independent risk factor for vein thromboembolism (VTE) is still somewhat controversial. Both genetic and nutritional factors influence...

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Source

Identifiers

PMID: 10397696
DOI: 10.1161/01.atv.19.7.1761

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10397696-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects.PMID 10397696Read ↗

Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease.Semantic proximity Read ↗

Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study.Semantic proximity Read ↗

Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis.Semantic proximity Read ↗

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The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status.Semantic proximity Read ↗

The mutation Ala677-->Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.Semantic proximity Read ↗

Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia.Semantic proximity Read ↗

Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study.Semantic proximity Read ↗

C677T methylenetetrahydrofolate reductase gene polymorphism as a risk factor involved in venous thromboembolism: a population-based case-control study.Semantic proximity Read ↗

Clinical Implications of Methylenetetrahydrofolate Reductase Mutations and Plasma Homocysteine Levels in Patients with Thromboembolic OcclusionSemantic proximity Read ↗

Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).Semantic proximity Read ↗

Hyperhomocysteinemia as a risk factor for venous thrombosis.Semantic proximity Read ↗

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