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Article

The ACE insertion/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature.

Current cancer drug targets - 1 May 2011

Ruiter Rikje, Visser Loes E, Van Duijn Cornelia M, Stricker Bruno H Ch

Abstract excerpt

The renin-angiotensin system (RAS) plays an important role in the regulation of the cardiovascular system. In addition to RAS enzymes in plasma, the RAS is present in various local organ systems. Moreover, local expression of the RAS has been shown in various malignant cells. In 1990, an insertion/deletion (I/D) polymorphism in the ACE gene was discovered, accounting for half of the variance of the serum ACE...

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Identifiers

PMID: 21395549
DOI: 10.2174/156800911795538147

Genes

ACE

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The ACE insertion/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature.PMID 21395549Read ↗

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