Article
MELPREDICT: a logistic regression model to estimate CDKN2A carrier probability.
Journal of medical genetics - 1 Jun 2006
Niendorf K B, Goggins W, Yang G, Tsai K Y, Shennan M, Bell D W, Sober A J, Hogg D, Tsao H
Abstract excerpt
BACKGROUND: Heritable alterations in CDKN2A account for a subset of familial melanoma cases although no robust method exists to identify those at risk of being a mutation carrier. METHODS: We set out to construct a model for estimating CDKN2A mutation carrier probability using a cohort of 116 consecutive familial cutaneous melanoma patients evaluated at Massachusetts General Hospital Pigmented Lesion Center...
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