Article
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
The Journal of biological chemistry - 25 Nov 2005
Ozawa Tatsuya, Araki Norie, Yunoue Shunji, Tokuo Hiroshi, Feng Liping, Patrakitkomjorn Siriporn, Hara Toshihiro, Ichikawa Yasuko, Matsumoto Kunio, Fujii Kiyotaka, Saya Hideyuki
Abstract excerpt
Neurofibromin is a neurofibromatosis type 1 (NF1) tumor suppressor gene product with a domain that acts as a GTPase-activating protein and functions, in part, as a negative regulator of Ras. Loss of neurofibromin expression in NF1 patients is associated with elevated Ras activity and increased cell proliferation, predisposing to a variety of tumors of the peripheral and central nervous systems. We show here,...
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