Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

doi:10.1158/0008-5472.CAN-04-3077

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Article

Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

Cancer research - 15 Sept 2005

Buchanan Grant, Birrell Stephen N, Peters Amelia A, Bianco-Miotto Tina, Ramsay Katrina, Cops Elisa J, Yang Miao, Harris Jonathan M, Simila Henry A, Moore Nicole L, Bentel Jacqueline M, Ricciardelli Carmella, Horsfall David J, Butler Lisa M, Tilley Wayne D

Abstract excerpt

Previously, we reported that androgen receptor (AR), but not estrogen receptor (ER) or progesterone receptor (PR), is predictive of response to the synthetic progestin, medroxyprogesterone acetate (MPA), in a cohort of 83 patients with metastatic breast cancer. To further investigate the role of AR in determining response to MPA in this cohort, we analyzed AR levels by immunohistochemistry with two discrete...

Topics

Animals
Antineoplastic Agents, Hormonal
Breast Neoplasms
COS Cells
Cell Line, Tumor
Chlorocebus aethiops
Drug Resistance, Neoplasm
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Medroxyprogesterone Acetate

Mutation

Postmenopause

Protein Conformation

Protein Isoforms

Radioligand Assay

Receptors, Androgen

Receptors, Estrogen

Source

Open in PubMed

Identifiers

PMID: 16166329
DOI: 10.1158/0008-5472.CAN-04-3077

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