Article
Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae.
The Journal of antimicrobial chemotherapy - 1 Nov 2005
Rouquette-Loughlin Corinne E, Balthazar Jacqueline T, Shafer William M
Abstract excerpt
OBJECTIVES: A homologue of the MacA-MacB ABC transporter of Escherichia coli, which recognizes and exports macrolides, was identified in Neisseria gonorrhoeae. This study was undertaken to determine whether gonococci could use the MacA-MacB homologue to express decreased susceptibility to macrolides. METHODS: Techniques of DNA sequencing, gene cloning and expression of recombinant proteins in E. coli, gene...
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